Scientist II, In Vivo, Enzymatic and Metabolic Therapeutic Area

ut Worldwide Research And Development**

From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases.

We are seeking a motivated Scientist with experience in genetic metabolic diseases to join our team. The Scientist will join the Enzymatic and Metabolic In Vivo team to design and execute key in vivo studies focused on developing therapeutics to transform the lives of people with genetic metabolic disorders. This role reports into the In Vivo Lead.

The primary role of the Scientist will be in design and execution of in vivo studies as part of the Enzymatic and Metabolic In Vivo Team. They will work collaboratively across the Research and Early Development Department to identify, develop and execute project strategies for in vivo testing of novel therapeutics. Areas of focus will span from animal model development to testing novel therapeutic approaches for genetic metabolic disorders.

The successful candidate will have a strong background in metabolic and enzymatic biology, with demonstrated experience in the use of model systems in research.

Experience with in vivo models of disease and a collaborative mindset is critical. While some industry experience is a plus, it is not required.

The successful candidate will contribute in vivo model evaluation and support to project teams that support the project goals. Including in vivo study design, hands on in vivo study performance, selection and characterization of animal models, as well as application of in vivo methods and techniques. Strong written communication skills are critical for FDA filings, writing IACUC protocols, communicating scientific strategy, monitoring in vivo studies and collaborating with CRO's, tissue collection, and sample management.

The successful candidate will also have experience with in vivo technical tasks including but not limited to dosing techniques (SC, IP, IV, RO, PO), blood collection (tail nick, saphenous vein puncture), and IVIS imaging.

The ideal candidate will have Postdoctoral Academic or Biotech/Pharma industry in vivo experience in the metabolic disease field. The ideal candidate will have hands-on experience with animal models of metabolic/enzymatic disease, a proven track record of high-quality science. Proficiency with in vivo methods such as administration of test articles, perfusion and tissue collection, blood collection, as well as rodent surgical models is required.

Candidate level at hire will depend on education and experience.
• *Responsibilities:**

Research Support
• Conduct research on genetic metabolic diseases
• Contribute to novel therapeutic programs based on innovative, ground-breaking discoveries that could lead to new, high-impact opportunities for patients
• Perform research and publish findings in high-impact journals and present research at major conferences
• Effectively partner with other scientists and the Research and Early Development team to develop and execute on the program's strategic plan
• Present program data at a range of internal forums, including project team meetings, Research Department Seminars and Research leadership governance forums
• Write, review and contribute to study synopses, protocols, study reports and regulatory documents
• Collaborate with various BioMarin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects
• Participate in multi-disciplinary drug development teams and may lead sub-teams
• Excellent written and verbal communication
• Ability to build/foster productive cross-functional collaborations both within and external to BioMarin
• Execute hands-on responsibilities including but not limited to animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection. In addition, providing daily care and monitoring of mice or rats, including health checks and documentation, will also be required.
• Follow all institutional, local, and federal regulatio