Principal Investigator | Physician

al Iowa, dedicated to improving the lives of adults and children living with diabetes, obesity, and related conditions. Through comprehensive clinical care, patient education, and innovative research, our team has conducted over 250 clinical studies and continues to make a meaningful impact on both individual health and the broader community.

This is your opportunity to step into clinical research leadership — where quality replaces volume, patients are engaged and motivated, and innovation is part of your daily work. We are seeking a Principal Investigator who wants to help shape the future of healthcare while restoring balance and purpose to their own career.

How We’re Different

We practice intentionally — in patient care, collaboration, and leadership. This is what truly sets us apart.

✔ Practice without pressure:
No RVU treadmill. No double-booked schedules. No rushed visits. Just relaxed, thoughtful, patient-focused care.

✔ Restore patient connection:
Our environment fosters motivated, invested, and engaged patients. This allows you to practice medicine the way it was meant to be.

✔ Drive innovation:
Play a direct role in advancing therapies that will redefine the future and set new standards in patient care.

✔ Enjoy true work-life balance:
Spend more time with patients. Deliver relaxed care. Forget EMR. Enjoy predictable, daytime hours at a sustainable pace.

✔ Join a culture that cares:
We work hard, invest in your success, value your expertise, and foster a culture where meaningful work and having fun go hand in hand.

✔ Advance your career:
Designed with growth in mind, this role offers the opportunity to advance toward Medical Directorship, with expanding clinical and organizational influence.

Role Highlights
• Job Type: 0.8 - 1.0 FTE
• Reports to: Chief Operating Officer (COO)
• Location: On-site in West Des Moines, Iowa
• Schedule: Day shift; occasional evenings and rare weekends as required by study or patient needs

What You Bring to the Team
Required skills and qualifications:
• Minimum 5 years clinical practice experience
• MD or DO from an accredited medical school
• Completion of accredited residency program
• Active medical license for the state of Iowa
• DEA registration and Iowa Controlled Substance Certificate (or ability to obtain)
• Prior clinical research experience or strong interest in research
• Proven leadership, communication, and analytical skills
• Strong commitment to ongoing education and growth

Preferred skills and qualifications:
• Board certified in Family Medicine, Endocrinology, or Internal Medicine
• Knowledge of FDA regulations and ICH-GCP
• Experience as Principal Investigator or Sub-Investigator
• Background in diabetes, obesity, or MASH research

How You’ll Make a Difference
• Serve as an Investigator, managing trials and ensuring compliance with FDA, GCP, ICH, HIPAA, IRB, and institutional policies.
• Complete all study training, review protocols, and train staff as needed.
• Assess patient eligibility and manage the informed consent process.
• Conduct physical exams, patient histories, diagnostic reviews, safety assessments, and treatment coordination.
• Review labs, imaging, and test results with sub-investigators and medical leadership.
• Educate patients on diabetes management, nutrition, activity, lifestyle, and device use per protocol.
• Oversee adverse events and serious adverse events, including treatment, referrals, and regulatory reporting.
• Lead, mentor, and supervise sub-investigators, coordinators, and study staff.
• Manage audits from sponsors, FDA, or other regulatory bodies and oversee corrective actions.
• Provide clinic care in-person or virtually during scheduled hours.
• Coordinate with affiliate or collaborating research sites for smooth multi-site operations.
• Respond promptly to patient calls, emails, and all internal communication.

Benefits That Support You
• Base Salary: Negotiable based on specialty
• Annual bonus based on productivity and quality
• Relocation Allowance (if applicable): $10,000
• Annual CME Allowance: $2,500
• 401(k) with up to 3% match
• Comprehensive medical, dental, and vision insurance
• Company-paid life insurance
• Short- and long-term disability
• Voluntary life, AD&D, critical illness, and identity theft protection
• Paid time off (PTO) + 6 company-paid holidays
• Defined pathway to Medical Director

Discover Your New Community

Not from Iowa? Pack your bags and get ready for your next adventure! We provide relocation assistance, competitive benefits, and everything you need to thrive in your new home and role. Read on to discover why we love living here - and why you will too.

Central Iowa combines bigger-city amenities with small-town friendliness, short commutes, and an affordable cost of living. Housing and everyday expenses are below the national average, making it easier to enjoy a comfortable lifestyle.

The city offers a vibrant arts, culture, and food scene, from the Downtown Des Moines Farmers’ Market and craft breweries to galleries, festivals, and farm-to table dining. Outdoor enthusiasts can enjoy miles of trails, parks, and riverfront spaces for walking, biking, and kayaking.

Central Iowa is family friendly and community focused, with strong schools, welcoming neighborhoods, and year-round activities. It’s a city where work-life balance is not just a goal, but a way of life!

See why so many professionals love living and working here:

Do Something Greater- Top Reasons to Live in Iowa 2026

The Cost of Living in the Greater Des Moines area, 2026

Des Moines Public Schools – Why Live in Central Iowa?

Ready to make a difference? Apply now! If you have any questions, please reach out to our People & Culture Partner: Mia Hughes at [email protected] or 515-207-5642