TMF Specialist

Allen Spolden

Hendersonville, TNFull-timePosted Apr 10, 2026

60K–80K a year

Behavioral Health Market Context

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Job Description

. This position will provide management and oversight of Trial Master File (TMF) filing activities to ensure audit and inspection readiness for clinical trials.

Responsibilities:
• Works with multi-functional study teams and vendors to ensure the maintenance of TMFs, both electronic and paper, in a state of inspection readiness.
• Maintains study-specific TMF Management Plan.
• Performing QC on TMF documents to ensure high quality per data quality standards and specified system guidelines
• Manages conduct of TMF quality reviews by cross-functional study team; driving to closure quality review findings.
• Supports the functional owners in the identification and management of the collection of study specific TMF content, (both sponsor and CRO).
• Assessing outstanding issues and following through to resolution
• Daily interaction with Clinical team, clinical project managers and members of the cross-functional study team.
• Plan, execute, and lead study-specific meetings.
• Follow international good clinical practice guidelines/regulations and standard operating procedures for executing clinical studies.
• Supports other trial-related operational activities as needed and assigned
Requirements
• Bachelor’s Degree Required
• 3-5 years of experience working in pharmaceutical/biotechnology or CRO organization in TMF management
• Working knowledge of VEEVA Vault
• Strong working knowledge of FDA & ICH/GCP regulations and guidelines and thorough knowledge of clinical monitoring procedures
• Proficient in computer technology used in an office environment (Microsoft Word, Excel, and PowerPoint) and Share point
• Exceptional attention to detail.
• Ability to work independently and collaboratively with excellent written communication, oral communication, and organizational skills are required
• Strong interest in clinical trials and initiative to learn and participate in projects of increasing responsibility
• Highly responsive and proactive, a team player
• Excellent communication and organizational skills and the ability to work effectively in a high-paced, fast changing environment.
• Flexible attitude with respect to work assignments and new learning
• Conscientious, influential person with an outstanding work ethic and strong personal discipline
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Qualifications

  • Bachelor’s Degree Required
  • 3-5 years of experience working in pharmaceutical/biotechnology or CRO organization in TMF management
  • Working knowledge of VEEVA Vault
  • Strong working knowledge of FDA & ICH/GCP regulations and guidelines and thorough knowledge of clinical monitoring procedures
  • Proficient in computer technology used in an office environment (Microsoft Word, Excel, and PowerPoint) and Share point
  • Exceptional attention to detail
  • Ability to work independently and collaboratively with excellent written communication, oral communication, and organizational skills are required
  • Strong interest in clinical trials and initiative to learn and participate in projects of increasing responsibility
  • Highly responsive and proactive, a team player
  • Excellent communication and organizational skills and the ability to work effectively in a high-paced, fast changing environment
  • Flexible attitude with respect to work assignments and new learning
  • Conscientious, influential person with an outstanding work ethic and strong personal discipline

Benefits

  • Work Experience 1-3 years

Responsibilities

  • The TMF Specialist is responsible for overseeing the overall management and quality of essential clinical trial documents to ensure compliance with applicable regulatory and local requirements
  • This position will provide management and oversight of Trial Master File (TMF) filing activities to ensure audit and inspection readiness for clinical trials
  • Works with multi-functional study teams and vendors to ensure the maintenance of TMFs, both electronic and paper, in a state of inspection readiness
  • Maintains study-specific TMF Management Plan
  • Performing QC on TMF documents to ensure high quality per data quality standards and specified system guidelines
  • Manages conduct of TMF quality reviews by cross-functional study team; driving to closure quality review findings
  • Supports the functional owners in the identification and management of the collection of study specific TMF content, (both sponsor and CRO)
  • Assessing outstanding issues and following through to resolution
  • Daily interaction with Clinical team, clinical project managers and members of the cross-functional study team
  • Plan, execute, and lead study-specific meetings
  • Follow international good clinical practice guidelines/regulations and standard operating procedures for executing clinical studies
  • Supports other trial-related operational activities as needed and assigned


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