Clinical Research Lab Associate

Benefits

Qualifications

• •Proficiency with general laboratory skills in a research laboratory setting outside the classroom, including: proficiency in cell culture, preparing and aliquoting solutions and samples , pipetting, maintaining a scientific notebook, electronic record keeping, and inventory management and organization;
• •Completed undergraduate courses (courses with lecture and laboratory components count as one course) in at least three of the following topics: general biology, molecular biology, genetics, microbiology, biochemistry, or toxicology;
• •At least six months of mentor-directed laboratory research experience in biological science outside the classroom;
• •Hands-on experience culturing mammalian cell lines in a laboratory setting;
• •Proficiency performing searches of the scientific literature using databases including PubMed; and
• •Proficiency with Microsoft Word, Excel, and Powerpoint software
• •NA synthesis, and quantitative PCR in a research laboratory setting
• •Proficiency in multiplex ELISA assays; and
• •Hands-on experience in Western blotting in a laboratory setting
• •Occasional overnight travel to scientific meetings to present research may also be required
• •7 more items(s)

Responsibilities

• •Within CPHEA, the Public Health and Integrated Toxicology Division (PHITD) performs clinical and animal toxicological research to assess the impact of environmental exposures on human health by developing and validating biological measures in all aspects of human health to better link exposure, dose, and health outcomes
• •This includes evaluating toxicological mechanisms and responses for target organ systems using multiple strategies related to chemical screening and prioritization including assessing in vivo predictive value of in vitro tests and test methods development and interpretation
• •Some division investigators conduct clinical studies involving human volunteers to determine the effects of exposure to ambient pollution on human health and elucidate the mechanisms through which these effects occur
• •Studies are conducted in close consultation with client offices in order to support the regulatory activities of the Agency
• •As a team member, your responsibilities will include general laboratory duties, project-based tasks, as well as technical and operational support
• •Specifically, the team member will assist in laboratory experiments aimed at understanding molecular mechanisms associated with adverse outcomes of pollutant exposure and biomarkers of susceptibility to the effects of air pollutant exposure
• •The team member will maintain cell cultures, conduct in vitro pollutant exposures, genotype samples, and assay gene and protein expression and function, as well as assist with clinical study operations and sample processing
• •The team member will also be expected to provide researcher support and contribute to project planning, data analyses, and communicate scientific findings
• •Through participation, the team member will learn a variety of fundamental and specialized biochemical and molecular techniques, as well as gain experience in translational clinical research studies
• •In addition, the team member will learn how to design and manage studies to address scientific questions, and how to prioritize, sequence, and troubleshoot experiments in order to maximize efficiency and productivity
• •The team member will work side by with trainees at various stages of their doctoral studies or postdoctoral fellowship and thus be exposed to advanced instruction in the planning and execution of laboratory protocols and clinical research operations
• •In addition, the team member will attend regular staff meetings in which findings and related scientific principles are presented and discussed
• •Participate as a member of a multi-disciplinary research team
• •Interact with other members of the development team as well as EPA scientists
• •Assist with coordination of clinical research operations
• •Proficiency in live cell research-based microscopy techniques, such as bright field and confocal fluorescent microscopy;
• •Travel: Occasional local travel may be required
• •14 more items(s)